When is it advised to use ARRAY CGH?
The use of array CGH (Comparative Genomic Hybridisation) is prescribed for patients with a normal karyotype and a clinical profile with:
- Unexplained intellectual disability or developmental delay.
- Congenital anomalies or dysmorphic features.
- Autistic disorders or clinical presentations that suggest a specific chromosomal syndrome.
It is also suggested for altered karyotypes:
- In patients with translocations that seem balanced with an abnormal clinical phenotype.
- In the presence of duplications or deletions in the karyotype in order to determine the limits of the altered region.
- When marker chromosomes are identified to determine the origin.
Why use this new technology?
Approximately 4% of births are children with intellectual disability. The array CGH has been recently introduced to identify chromosomal alternations in patients with pathological conditions, but without any alterations in the karyotype.
During this time, it has been revealed that this technology is more sensitive and efficient than the conventional karyotyping, as the solution of the array CGH is at least ten times higher than conventional karyotyping.
Bioarray has Cytoarray available, an array CGH that covers the complete genome with different resolutions of 60K, 180K and 400K.
CYTOARRAY AND CYTOARRAY PLUS
Cytoarray and Cytoarray Plus are two array CGH specifically designed to detect intellectual disabilities caused by the loss (microdeletions) or gain (microduplications) of genetic material.
Cytoarray suggests a new clinical focus, as a suspicion of the syndrome that the child suffers from is not required. By applying traditional protocols, children and their parents have to go through months of endless tests (karyotyping, high-resolution karyotyping, subtelomeric bands, etc.)
When considering, at first, the higher capacity diagnostic test, we achieve the following:
- A shorter waiting time to find out the diagnosis. Cytoarray offers results in 15 days.
- Avoiding sequential or partial tests. Cytoarray is a test with a higher diagnostic capacity, as it fully scans the genome.
- Eliminating the problems caused by travelling and taking samples. Cytoarray only needs a blood or saliva sample which can be done at your medical centre or nearest laboratory.
- Drastically reducing the economic cost of the diagnosis.