Glycogenosis encompasses a set of inherited diseases characterized by altered metabolism of glycogen in the body tissues, particularly affecting those where it is most needed: muscle and liver.
GSD is the result of a genetic deficiency in any of the genes vinculed to enzymes in the pathways of glycogen metabolism, either for their synthesis or degradation.
Cori described in 1952 the first glycogenosis. In this case it was associated with a deficiency in glucose-6-phosphatase. However, studies about glycogen storaged diseases were expanded until today.